[HTML][HTML] Regulation of complexed and free catenin pools by distinct mechanisms: differential effects of Wnt-1 and v-Src
J Papkoff - Journal of Biological Chemistry, 1997 - ASBMB
Cadherins are transmembrane receptors with an extracellular domain that participates in
homophilic cell to cell adhesion and a cytoplasmic domain that associates with proteins
called catenins. Cadherin-mediated adhesion as well as adhesion-independent functions
for catenins play important roles in differentiation, development, and malignant
transformation. Mechanisms that regulate steady-state catenin levels and cadherin-catenin
complex stability are poorly understood, but activities of both the Wnt-1 proto-oncogene and …
homophilic cell to cell adhesion and a cytoplasmic domain that associates with proteins
called catenins. Cadherin-mediated adhesion as well as adhesion-independent functions
for catenins play important roles in differentiation, development, and malignant
transformation. Mechanisms that regulate steady-state catenin levels and cadherin-catenin
complex stability are poorly understood, but activities of both the Wnt-1 proto-oncogene and …