[HTML][HTML] Opposite regulation of type II and III receptors for immunoglobulin G in mouse glomerular mesangial cells and in the induction of anti-glomerular basement …
HH Radeke, I Janssen-Graalfs, EN Sowa… - Journal of Biological …, 2002 - ASBMB
We examined the capacity of mouse glomerular mesangial cells (MC) to express and
function through two different low affinity FcγRs, the activating FcγRIII and the inhibitory
FcγRII. Immunohistochemistry identified FcγRII as the prominent FcγR in the kidney, and low
levels of FcγRIIb2-specific mRNA were also detected in primary cultures of growth-arrested
MC. Activation by tumor necrosis factor-α/interleukin-1β induced substantial FcγRII
expression in proliferating MC. Importantly, however, stimulation with interferon-γ (IFN …
function through two different low affinity FcγRs, the activating FcγRIII and the inhibitory
FcγRII. Immunohistochemistry identified FcγRII as the prominent FcγR in the kidney, and low
levels of FcγRIIb2-specific mRNA were also detected in primary cultures of growth-arrested
MC. Activation by tumor necrosis factor-α/interleukin-1β induced substantial FcγRII
expression in proliferating MC. Importantly, however, stimulation with interferon-γ (IFN …
