Δ9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells
M Yuan, SM Kiertscher, Q Cheng, R Zoumalan… - Journal of …, 2002 - Elsevier
Human leukocytes express cannabinoid (CB) receptors, suggesting a role for both
endogenous ligands and Δ9-tetrahydrocannabinol (THC) as immune modulators. To
evaluate this, human T cells were stimulated with allogeneic dendritic cells (DC) in the
presence or absence of THC (0.625–5 μg/ml). THC suppressed T cell proliferation, inhibited
the production of interferon-γ and shifted the balance of T helper 1 (Th1)/T helper 2 (Th2)
cytokines. Intracellular cytokine staining demonstrated that THC reduced both the …
endogenous ligands and Δ9-tetrahydrocannabinol (THC) as immune modulators. To
evaluate this, human T cells were stimulated with allogeneic dendritic cells (DC) in the
presence or absence of THC (0.625–5 μg/ml). THC suppressed T cell proliferation, inhibited
the production of interferon-γ and shifted the balance of T helper 1 (Th1)/T helper 2 (Th2)
cytokines. Intracellular cytokine staining demonstrated that THC reduced both the …
