[HTML][HTML] Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profiling
DA Tice, W Szeto, I Soloviev, B Rubinfeld… - Journal of Biological …, 2002 - ASBMB
Novel drug targets can be identified by differential analysis of RNA transcripts isolated from
cancer cell lines and tissues. We have extended this approach by analyzing differences in
gene expression resulting from the drug treatment of transformed and nontransformed cells.
A mouse mammary epithelial cell line (C57MG), which conditionally expresses the Wnt-1
proto-oncogene, was left untreated or treated with retinoic acid in the presence or absence
of Wnt-1 expression. The experiment was performed in triplicate, and RNA extracted from …
cancer cell lines and tissues. We have extended this approach by analyzing differences in
gene expression resulting from the drug treatment of transformed and nontransformed cells.
A mouse mammary epithelial cell line (C57MG), which conditionally expresses the Wnt-1
proto-oncogene, was left untreated or treated with retinoic acid in the presence or absence
of Wnt-1 expression. The experiment was performed in triplicate, and RNA extracted from …