[HTML][HTML] Slc26a9 is inhibited by the R-region of the cystic fibrosis transmembrane conductance regulator via the STAS domain
SLC26 proteins function as anion exchangers, channels, and sensors. Previous cellular
studies have shown that Slc26a3 and Slc26a6 interact with the R-region of the cystic fibrosis
transmembrane conductance regulator (CFTR),(R) CFTR, via the Slc26-STAS (sulfate
transporter anti-sigma) domain, resulting in mutual transport activation. We recently showed
that Slc26a9 has both nCl−-HCO 3− exchanger and Cl− channel function. In this study, we
show that the purified STAS domain of Slc26a9 (a9STAS) binds purified (R) CFTR. When …
studies have shown that Slc26a3 and Slc26a6 interact with the R-region of the cystic fibrosis
transmembrane conductance regulator (CFTR),(R) CFTR, via the Slc26-STAS (sulfate
transporter anti-sigma) domain, resulting in mutual transport activation. We recently showed
that Slc26a9 has both nCl−-HCO 3− exchanger and Cl− channel function. In this study, we
show that the purified STAS domain of Slc26a9 (a9STAS) binds purified (R) CFTR. When …