[HTML][HTML] hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels
A Gibson, AP Lewis, K Affleck, AJ Aitken… - Journal of Biological …, 2005 - ASBMB
Proteins of the CLCA gene family have been proposed to mediate calcium-activated
chloride currents. In this study, we used detailed bioinformatics analysis and found that no
transmembrane domains are predicted in hCLCA1 or mCLCA3 (Gob-5). Further analysis
suggested that they are globular proteins containing domains that are likely to be involved in
protein-protein interactions. In support of the bioinformatics analysis, biochemical studies
showed that hCLCA1 and mCLCA3, when expressed in HEK293 cells, could be removed …
chloride currents. In this study, we used detailed bioinformatics analysis and found that no
transmembrane domains are predicted in hCLCA1 or mCLCA3 (Gob-5). Further analysis
suggested that they are globular proteins containing domains that are likely to be involved in
protein-protein interactions. In support of the bioinformatics analysis, biochemical studies
showed that hCLCA1 and mCLCA3, when expressed in HEK293 cells, could be removed …
