The relevance of tumour pH to the treatment of malignant disease
JL Wike-Hooley, J Haveman, HS Reinhold - Radiotherapy and Oncology, 1984 - Elsevier
Interest in tumour pH stems from the early part of this century, when the pioneering work of
Otto Warburg first suggested that aerobic glycolysis was a characteristic property of
malignant cells [134]. Warburg hypothesized that the respiration of tumour cells was"
damaged" such that they preferentially metabolized via anaerobic pathways, producing
large quantities of lactic acid. This in its turn would render malignant tissue more acidic,
which led to the early attempts to measure tissue pH in various extracts and homogenates …
Otto Warburg first suggested that aerobic glycolysis was a characteristic property of
malignant cells [134]. Warburg hypothesized that the respiration of tumour cells was"
damaged" such that they preferentially metabolized via anaerobic pathways, producing
large quantities of lactic acid. This in its turn would render malignant tissue more acidic,
which led to the early attempts to measure tissue pH in various extracts and homogenates …
