Microvascular complications in diabetes contribute to pathologic and functional changes in
many tissues, including eye, heart, kidney, skin, and neuronal tissues. Based on the tissues
affected, these changes are traditionally known as diabetic retinopathy, nephropathy, and
neuropathy, respectively. In addition to these classic complications, pathologic changes in
the microvessels of the myocardium reduce cardiac contractility, and ventricular dysfunction
is often observed in diabetic patients. The development and progression of microvascular …