Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy
KC Nadeau, LC Schneider, L Hoyte, I Borras… - Journal of Allergy and …, 2011 - jacionline.org
To the Editor: We conducted a pilot phase I study in 11 children (age, 7-17 years) with cow's
milk allergy by using omalizumab (anti-IgE mAb; Xolair; Genentech, South San Francisco,
Calif) in combination with relatively rapid oral milk desensitization. We hypothesized that
oral desensitization might occur rapidly and with few side effects when performed with
omalizumab. Our primary objectives were to examine the safety of this approach and to
determine whether subjects could be dosed up to 2000 mg milk within 7 to 11 weeks of …
milk allergy by using omalizumab (anti-IgE mAb; Xolair; Genentech, South San Francisco,
Calif) in combination with relatively rapid oral milk desensitization. We hypothesized that
oral desensitization might occur rapidly and with few side effects when performed with
omalizumab. Our primary objectives were to examine the safety of this approach and to
determine whether subjects could be dosed up to 2000 mg milk within 7 to 11 weeks of …
