Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
A Ogawa, A Andoh, Y Araki, T Bamba, Y Fujiyama - Clinical immunology, 2004 - Elsevier
We evaluated the effects of rat anti-mouse IL-17 neutralizing monoclonal antibody (mAb) on
the development of dextran sulfate sodium (DSS)-induced colitis. Tissue samples were
evaluated by standard immunohistochemical procedure. The mucosal mRNA expression of
cytokines was analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR). In
the mice treated with the anti-IL-17 mAb, the body weight was significantly lower, and anal
prolapse and colon shortening were apparent. A histological analysis indicated that the anti …
the development of dextran sulfate sodium (DSS)-induced colitis. Tissue samples were
evaluated by standard immunohistochemical procedure. The mucosal mRNA expression of
cytokines was analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR). In
the mice treated with the anti-IL-17 mAb, the body weight was significantly lower, and anal
prolapse and colon shortening were apparent. A histological analysis indicated that the anti …
