Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines
AL Cox, J Skipper, Y Chen, RA Henderson, TL Darrow… - Science, 1994 - science.org
Science, 1994•science.org
Of several thousand peptides presented by the major histocompatibility molecule HLA-A2. 1,
at least nine are recognized by melanoma-specific cytotoxic T lymphocytes (CTLs). Tandem
mass spectrometry was used to identify and to sequence one of these peptide epitopes.
Melanoma-specific CTLs had an exceptionally high affinity for this nine-residue peptide,
which reconstituted an epitope for CTL lines from each of five different melanoma patients
tested. Recognition by multiple CTL lines suggests that this may be a promising candidate …
at least nine are recognized by melanoma-specific cytotoxic T lymphocytes (CTLs). Tandem
mass spectrometry was used to identify and to sequence one of these peptide epitopes.
Melanoma-specific CTLs had an exceptionally high affinity for this nine-residue peptide,
which reconstituted an epitope for CTL lines from each of five different melanoma patients
tested. Recognition by multiple CTL lines suggests that this may be a promising candidate …
Of several thousand peptides presented by the major histocompatibility molecule HLA-A2.1, at least nine are recognized by melanoma-specific cytotoxic T lymphocytes (CTLs). Tandem mass spectrometry was used to identify and to sequence one of these peptide epitopes. Melanoma-specific CTLs had an exceptionally high affinity for this nine-residue peptide, which reconstituted an epitope for CTL lines from each of five different melanoma patients tested. Recognition by multiple CTL lines suggests that this may be a promising candidate for use in peptide-based melanoma vaccines.
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