[HTML][HTML] LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver
C Gnerre, GU Schuster, A Roth, C Handschin… - Journal of lipid …, 2005 - ASBMB
Metabolic transformation by the superfamily of cytochromes P450 (CYPs) plays an important
role in the detoxification of xenobiotics such as drugs, environmental pollutants, and food
additives. Endogenous substrates of CYPs include fatty acids, sterols, steroids, and bile
acids. Induction of CYPs via transcriptional activation by substrates and other xenobiotics is
an important adaptive mechanism that increases the organism's defense capability against
toxicity. Numerous in vivo and in vitro data have highlighted the concept that the molecular …
role in the detoxification of xenobiotics such as drugs, environmental pollutants, and food
additives. Endogenous substrates of CYPs include fatty acids, sterols, steroids, and bile
acids. Induction of CYPs via transcriptional activation by substrates and other xenobiotics is
an important adaptive mechanism that increases the organism's defense capability against
toxicity. Numerous in vivo and in vitro data have highlighted the concept that the molecular …