[HTML][HTML] Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis
S Bhatnagar, HA Damron, FB Hillgartner - Journal of Biological Chemistry, 2009 - ASBMB
Previous studies have shown that administration of fibroblast growth factor-19 (FGF-19)
reverses diabetes, hepatic steatosis, hyperlipidemia, and adipose accretion in animal
models of obesity. To investigate the mechanism for this effect, we determined whether FGF-
19 modulated hepatic fatty acid synthesis, a key process controlling glucose tolerance and
triacylglycerol accumulation in liver, blood, and adipose tissue. Incubating primary
hepatocyte cultures with recombinant FGF-19 suppressed the ability of insulin to stimulate …
reverses diabetes, hepatic steatosis, hyperlipidemia, and adipose accretion in animal
models of obesity. To investigate the mechanism for this effect, we determined whether FGF-
19 modulated hepatic fatty acid synthesis, a key process controlling glucose tolerance and
triacylglycerol accumulation in liver, blood, and adipose tissue. Incubating primary
hepatocyte cultures with recombinant FGF-19 suppressed the ability of insulin to stimulate …