Taxol produces neuropathic pain with three distinct zones of involvement in the extremities.
Most distally is an area of on-going pain and proximal to this is a zone of sensory
disturbance but not overt pain. These two areas were confined in all but one case to the
glabrous skin of the hands and/or feet. More proximal is an area not recognized by the
patients as involved with pain or sensory disturbance yet wherein quantitative sensory tests
nevertheless reveal altered sensibility. Impairment of perception to light touch, normally …