Vagal sensory afferents innervating airways and abdominal tissues express TRPV1 and
TRPA1, two depolarizing calcium permeable ion channels playing a major role in sensing
environmental irritants and endogenous metabolites which cause neuropeptide release and
neurogenic inflammation. Here we have studied axonal chemosensitivity and control of
neuropeptide release from the isolated rat and mouse vagus nerve by using prototypical
agonists of these transduction channels–capsaicin, mustard oil and the specific endogenous …