[HTML][HTML] Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells
T Coll, E Eyre, R Rodríguez-Calvo, X Palomer… - Journal of biological …, 2008 - ASBMB
Here we report that in skeletal muscle cells the contribution to insulin resistance and
inflammation of two common dietary long-chain fatty acids depends on the channeling of
these lipids to distinct cellular metabolic fates. Exposure of cells to the saturated fatty acid
palmitate led to enhanced diacylglycerol levels and the consequent activation of the protein
kinase Cθ/nuclear factor κB pathway, finally resulting in enhanced interleukin 6 secretion
and down-regulation of the expression of genes involved in the control of the oxidative …
inflammation of two common dietary long-chain fatty acids depends on the channeling of
these lipids to distinct cellular metabolic fates. Exposure of cells to the saturated fatty acid
palmitate led to enhanced diacylglycerol levels and the consequent activation of the protein
kinase Cθ/nuclear factor κB pathway, finally resulting in enhanced interleukin 6 secretion
and down-regulation of the expression of genes involved in the control of the oxidative …