Obesity is an independent risk factor for cardiac failure. Obesity promotes excessive
deposition of fat in adipose and nonadipose tissues. Intramyocardial lipid overload is a
relatively common finding in nonischemic heart failure, especially in obese and diabetic
patients, and promotes lipoapoptosis that contributes to the alteration of cardiac function.
Lipoprotein production has been proposed as a heart-protective mechanism through the
unloading of surplus cellular lipids. We previously analyzed the heart transcriptome in a dog …