Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A
T Honda, KT Liby, X Su, C Sundararajan… - Bioorganic & medicinal …, 2006 - Elsevier
Bioorganic & medicinal chemistry letters, 2006•Elsevier
Fifteen new betulinic acid analogues were designed, synthesized, and tested for anti-
inflammatory activity. Many of these analogues effectively suppress nitric oxide (NO)
production in RAW cells stimulated with interferon-γ. Analogue 10 is highly and orally active
in vivo for induction of the anti-inflammatory and cytoprotective enzyme, heme oxygenase-1.
inflammatory activity. Many of these analogues effectively suppress nitric oxide (NO)
production in RAW cells stimulated with interferon-γ. Analogue 10 is highly and orally active
in vivo for induction of the anti-inflammatory and cytoprotective enzyme, heme oxygenase-1.
Fifteen new betulinic acid analogues were designed, synthesized, and tested for anti-inflammatory activity. Many of these analogues effectively suppress nitric oxide (NO) production in RAW cells stimulated with interferon-γ. Analogue 10 is highly and orally active in vivo for induction of the anti-inflammatory and cytoprotective enzyme, heme oxygenase-1.
Elsevier