Barley-derived β-D-glucan induces immunostimulation via a dectin-1-mediated pathway
R Tada, F Ikeda, K Aoki, M Yoshikawa, Y Kato… - Immunology letters, 2009 - Elsevier
Barley-derived β-glucan, a linear mixed-linkage β-glucan composed of 1, 3-and 1, 4-β-d-
glucopyranose polymers, binds to dectin-1. However, whether it can trigger signal
transduction via dectin-1 remains unclear. In this study, we used a reporter gene assay to
determine whether barley-derived β-d-glucan can activate NF-κB via dectin-1-mediated
signaling when dectin-1 is cotransfected with Syk, CARD9, and Bcl10 in 293T cells. We
found that barley-derived β-d-glucan can activate NF-κB leading to cytokine production …
glucopyranose polymers, binds to dectin-1. However, whether it can trigger signal
transduction via dectin-1 remains unclear. In this study, we used a reporter gene assay to
determine whether barley-derived β-d-glucan can activate NF-κB via dectin-1-mediated
signaling when dectin-1 is cotransfected with Syk, CARD9, and Bcl10 in 293T cells. We
found that barley-derived β-d-glucan can activate NF-κB leading to cytokine production …