CARMA1, BCL-10 and MALT1 in lymphocyte development and activation
M Thome - Nature Reviews Immunology, 2004 - nature.com
Nature Reviews Immunology, 2004•nature.com
Abstract CARMA1, BCL-10 and MALT1 are signalling proteins that have a key role in
antigen-receptor-mediated lymphocyte activation through the nuclear factor-κB pathway.
Recent genetic studies have revealed additional, previously unexpected roles for these
proteins in the development of B and T cells, and in the CD40-and lipopolysaccharide-
dependent activation of B cells. Here, I discuss recent advances in the understanding of the
molecular and biological functions of these proteins.
antigen-receptor-mediated lymphocyte activation through the nuclear factor-κB pathway.
Recent genetic studies have revealed additional, previously unexpected roles for these
proteins in the development of B and T cells, and in the CD40-and lipopolysaccharide-
dependent activation of B cells. Here, I discuss recent advances in the understanding of the
molecular and biological functions of these proteins.
Abstract
CARMA1, BCL-10 and MALT1 are signalling proteins that have a key role in antigen-receptor-mediated lymphocyte activation through the nuclear factor-κB pathway. Recent genetic studies have revealed additional, previously unexpected roles for these proteins in the development of B and T cells, and in the CD40- and lipopolysaccharide-dependent activation of B cells. Here, I discuss recent advances in the understanding of the molecular and biological functions of these proteins.
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