This study disclosed the close correlation between the characteristic developmental change
of human cerebral vessels and the occurrence of periventricular leukomalacia (PVL), as
judged by anticollagen type 6 immunohistochemical analysis. The earlier appearance of
collagen type 6–positive vessels in the deep white matter supports the concept that the
medullary vein, a terminal branch of the internal cerebral vein, develops earlier than the
cortical and subcortical veins and the perforating artery because the latter was not stained in …