Inefficient termination of antigen responses in NF-ATp-deficient mice
J Heyer, B Kneitz, K Schuh, E Jankevics, F Siebelt… - Immunobiology, 1997 - Elsevier
In order to elucidate the role of NF-ATp, one of the most prominent members of family of NF-
AT transcription factors in peripheral T lymphocytes, in T cell activation and differentiation we
created NF-ATp-deficient mice by gene targeting. Such NF-ATp-/-mice are born and appear
to develop a normal immune system. Apart from clear-cut defects in the synthesis of mRNAs
for Th2-type lymphokines, such as IL-4, IL-5, IL-10 and IL-13, in primary and secondary
stimulations of spleen cells in vitro, of a distinct impaired deletion of Vβ11+/CD4+ T …
AT transcription factors in peripheral T lymphocytes, in T cell activation and differentiation we
created NF-ATp-deficient mice by gene targeting. Such NF-ATp-/-mice are born and appear
to develop a normal immune system. Apart from clear-cut defects in the synthesis of mRNAs
for Th2-type lymphokines, such as IL-4, IL-5, IL-10 and IL-13, in primary and secondary
stimulations of spleen cells in vitro, of a distinct impaired deletion of Vβ11+/CD4+ T …
