Lesional accumulation of heme oxygenase-1+ microglia/macrophages in rat traumatic brain injury
Y Liu, Z Zhang, B Luo, HJ Schluesener, Z Zhang - Neuroreport, 2013 - journals.lww.com
Abstract Heme oxygenase-1 (HO-1) is an inducible rate-limiting enzyme for heme
degradation. Here, we studied the HO-1 expression in an open-skull weight-drop-induced
traumatic brain injury, with a focus on the early phase, most amenable to therapy. In normal
rat brains of our study, HO-1+ cells were rarely observed. Significant parenchymal
accumulation of HO-1+ non-neuron cells was observed 18 h post-traumatic brain injury and
increased continuously during the investigating time. We also observed that the …
degradation. Here, we studied the HO-1 expression in an open-skull weight-drop-induced
traumatic brain injury, with a focus on the early phase, most amenable to therapy. In normal
rat brains of our study, HO-1+ cells were rarely observed. Significant parenchymal
accumulation of HO-1+ non-neuron cells was observed 18 h post-traumatic brain injury and
increased continuously during the investigating time. We also observed that the …