Glatiramer acetate (GA, Copolymer-1) an hypothetical treatment option for Rett syndrome
B Ben-Zeev, R Aharoni, A Nissenkorn, R Arnon - Medical Hypotheses, 2011 - Elsevier
Rett syndrome (RTT) is an X-linked dominant postnatal severe and disabling
neurodevelopmental disorder which is the second most common cause for genetic mental
retardation in girls and the first pervasive disorder with a known genetic basis. The
syndrome is primarily caused by mutations in the Methyl CpG binding protein 2 (MECP2)
gene on Xq28. Its protein product MeCP2 acts as a transcriptional repressor or activator
depending on the target gene associated. Brain derived neurotrophic factor (BDNF) is a …
neurodevelopmental disorder which is the second most common cause for genetic mental
retardation in girls and the first pervasive disorder with a known genetic basis. The
syndrome is primarily caused by mutations in the Methyl CpG binding protein 2 (MECP2)
gene on Xq28. Its protein product MeCP2 acts as a transcriptional repressor or activator
depending on the target gene associated. Brain derived neurotrophic factor (BDNF) is a …
