Radiosensitizing effects of ectopic miR-101 on non–small-cell lung cancer cells depend on the endogenous miR-101 Level
S Chen, H Wang, WL Ng, WJ Curran, Y Wang - International Journal of …, 2011 - Elsevier
PURPOSE: Previously, we showed that ectopic miR-101 could sensitize human tumor cells
to radiation by targeting ATM and DNA-PK catalytic subunit (DNA-PKcs) to inhibit DNA
repair, as the endogenous miR-101 levels are low in tumors in general. However, the
heterogeneity of human cancers may result in an exception. The purpose of this study was to
test the hypothesis that a few tumor cell lines with a high level of endogenous miR-101
would prove less response to ectopic miR-101. METHODS AND MATERIALS: Fourteeen …
to radiation by targeting ATM and DNA-PK catalytic subunit (DNA-PKcs) to inhibit DNA
repair, as the endogenous miR-101 levels are low in tumors in general. However, the
heterogeneity of human cancers may result in an exception. The purpose of this study was to
test the hypothesis that a few tumor cell lines with a high level of endogenous miR-101
would prove less response to ectopic miR-101. METHODS AND MATERIALS: Fourteeen …
