[HTML][HTML] Deletion of tumor necrosis factor-α receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis
T Romanatto, EA Roman, AP Arruda, RG Denis… - Journal of biological …, 2009 - ASBMB
In diet-induced obesity, hypothalamic and systemic inflammatory factors trigger intracellular
mechanisms that lead to resistance to the main adipostatic hormones, leptin and insulin.
Tumor necrosis factor-α (TNF-α) is one of the main inflammatory factors produced during this
process and its mechanistic role as an inducer of leptin and insulin resistance has been
widely investigated. Most of TNF-α inflammatory signals are delivered by TNF receptor 1
(R1); however, the role played by this receptor in the context of obesity-associated …
mechanisms that lead to resistance to the main adipostatic hormones, leptin and insulin.
Tumor necrosis factor-α (TNF-α) is one of the main inflammatory factors produced during this
process and its mechanistic role as an inducer of leptin and insulin resistance has been
widely investigated. Most of TNF-α inflammatory signals are delivered by TNF receptor 1
(R1); however, the role played by this receptor in the context of obesity-associated …