Endogenous glucocorticoids regulate a variety of physiologic processes and are crucial to
the systemic stress response. Glucocorticoid receptors are expressed throughout the body,
but there is considerable heterogeneity in glucocorticoid sensitivity and induced biological
responses across tissues. The immunoregulatory properties of glucocorticoids are exploited
in the clinic for the treatment of inflammatory and autoimmune disorders as well as certain
hematological malignancies, but adverse side effects hamper prolonged use. Fully …