Significance of T helper 17 immunity in transplantation
F Abadja, B Sarraj, MJ Ansari - Current opinion in organ …, 2012 - journals.lww.com
F Abadja, B Sarraj, MJ Ansari
Current opinion in organ transplantation, 2012•journals.lww.comTh17 immunity is now beginning to be appreciated as a set of responses mediated not only
by CD4 Th17 cells but a variety of immune cells and a plethora of cytokines that collaborate
to mediate immune disorders, including transplant rejection. Development and contribution
of de-novo autoimmunity to chronic rejection is increasingly appreciated. The developmental
plasticity of Tregs and Th17 cells is a major hurdle to Treg-based cellular therapies for
transplantation. Several biologics targeting Th17 immunity are under evaluation for …
by CD4 Th17 cells but a variety of immune cells and a plethora of cytokines that collaborate
to mediate immune disorders, including transplant rejection. Development and contribution
of de-novo autoimmunity to chronic rejection is increasingly appreciated. The developmental
plasticity of Tregs and Th17 cells is a major hurdle to Treg-based cellular therapies for
transplantation. Several biologics targeting Th17 immunity are under evaluation for …
Summary
Th17 immunity is now beginning to be appreciated as a set of responses mediated not only by CD4 Th17 cells but a variety of immune cells and a plethora of cytokines that collaborate to mediate immune disorders, including transplant rejection. Development and contribution of de-novo autoimmunity to chronic rejection is increasingly appreciated. The developmental plasticity of Tregs and Th17 cells is a major hurdle to Treg-based cellular therapies for transplantation. Several biologics targeting Th17 immunity are under evaluation for autoimmune disease. It remains to be determined whether these can be used in transplantation to improve outcomes.
Lippincott Williams & Wilkins