As a consequence of an advancing discrepancy between supply of suitable grafts and
demand from potential recipients, less than optimal organs are increasingly being used.
Although clinical studies demonstrate the involvement of various risk factors, including donor
age and duration of ischemia on long-term graft outcome, their individual contribution and
correlation has not been followed experimentally. After cold ischemic times of 5, 60, and 120
min, kidney allografts of 3-, 12-, and 18-mo-old Fischer 344 donors were transplanted into 3 …