[HTML][HTML] Intrarenal B cell cytokines promote transplant fibrosis and tubular atrophy
GH Tse, CJC Johnston, D Kluth, M Gray, D Gray… - American Journal of …, 2015 - Elsevier
Renal transplantation is the optimum treatment for end-stage renal failure. B cells have been
identified in chronic allograft damage (CAD) and associated with the development of tertiary
lymphoid tissue within the human renal allograft. We performed renal transplantation in mice
to model CAD and identified B cells forming tertiary lymphoid tissue with germinal centers.
Intra-allograft B220+ B cells comprised of IgM high CD23− B cells, IgM lo CD23+ B cells,
and IgM lo CD23− B cells with elevated expression of CD86. Depletion of B cells with anti …
identified in chronic allograft damage (CAD) and associated with the development of tertiary
lymphoid tissue within the human renal allograft. We performed renal transplantation in mice
to model CAD and identified B cells forming tertiary lymphoid tissue with germinal centers.
Intra-allograft B220+ B cells comprised of IgM high CD23− B cells, IgM lo CD23+ B cells,
and IgM lo CD23− B cells with elevated expression of CD86. Depletion of B cells with anti …