[HTML][HTML] Lower calcineurin inhibitor doses in older compared to younger kidney transplant recipients yield similar troughs
PA Jacobson, D Schladt, WS Oetting, R Leduc… - American Journal of …, 2012 - Elsevier
The number of older adults undergoing kidney transplantation has increased, yet little is
known about calcineurin inhibitor (CNI) metabolism in this group. We studied CNI troughs
and doses to determine if there were age-related differences in metabolism and dose
requirements. We studied 348 young (18–34 years), 1831 middle (35–64 years) and 374
older (65–84 years) adult kidney transplant recipients enrolled in a seven-center prospective
study. Troughs were obtained from each patient 2×/week in weeks 1–8 and 2×/month in …
known about calcineurin inhibitor (CNI) metabolism in this group. We studied CNI troughs
and doses to determine if there were age-related differences in metabolism and dose
requirements. We studied 348 young (18–34 years), 1831 middle (35–64 years) and 374
older (65–84 years) adult kidney transplant recipients enrolled in a seven-center prospective
study. Troughs were obtained from each patient 2×/week in weeks 1–8 and 2×/month in …