Role of the nuclear lamina in genome organization and gene expression
D Peric-Hupkes, B van Steensel - Cold Spring Harbor …, 2010 - symposium.cshlp.org
D Peric-Hupkes, B van Steensel
Cold Spring Harbor symposia on quantitative biology, 2010•symposium.cshlp.orgThe nuclear lamina is a major structural component of metazoan nuclei that has long been
thought to provide an anchoring site for interphase chromosomes and have a role in gene
regulation. Recent genome-wide mapping studies and functional experimental data strongly
support these roles of the nuclear lamina. Here, we discuss new insights into various
aspects of genome–nuclear lamina interactions, with emphasis on the links with gene
regulation and with dynamics during cellular differentiation.
thought to provide an anchoring site for interphase chromosomes and have a role in gene
regulation. Recent genome-wide mapping studies and functional experimental data strongly
support these roles of the nuclear lamina. Here, we discuss new insights into various
aspects of genome–nuclear lamina interactions, with emphasis on the links with gene
regulation and with dynamics during cellular differentiation.
Abstract
The nuclear lamina is a major structural component of metazoan nuclei that has long been thought to provide an anchoring site for interphase chromosomes and have a role in gene regulation. Recent genome-wide mapping studies and functional experimental data strongly support these roles of the nuclear lamina. Here, we discuss new insights into various aspects of genome–nuclear lamina interactions, with emphasis on the links with gene regulation and with dynamics during cellular differentiation.
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