MeCP2 as an activator of gene expression
PM Horvath, LM Monteggia - Trends in neurosciences, 2018 - cell.com
Trends in neurosciences, 2018•cell.com
Rett syndrome is a neurodevelopmental disorder that primarily affects females and is
caused by mutations in the methyl-CpG-binding-protein 2 (MECP2) gene. Initially, MeCP2
had been shown to be a repressor of gene transcription. In their 2008 paper, Chahrour and
colleagues reported that MeCP2 could also function as a transcriptional activator.
caused by mutations in the methyl-CpG-binding-protein 2 (MECP2) gene. Initially, MeCP2
had been shown to be a repressor of gene transcription. In their 2008 paper, Chahrour and
colleagues reported that MeCP2 could also function as a transcriptional activator.
Rett syndrome is a neurodevelopmental disorder that primarily affects females and is caused by mutations in the methyl-CpG-binding-protein 2 (MECP2) gene. Initially, MeCP2 had been shown to be a repressor of gene transcription. In their 2008 paper, Chahrour and colleagues reported that MeCP2 could also function as a transcriptional activator.
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