BACKGROUND: Fibroblast growth factor (FGF) signaling controls self-renewal of neural
stem cells during embryonic telencephalic development. FGF receptor 2 (FGFR2) has a
significant role in the production of cortical neurons during embryogenesis, but its role in the
hippocampus during development and in adulthood has not been described. METHODS:
Here we dissociate the role of FGFR2 in the hippocampus during development and during
adulthood with the use of embryonic knockout and inducible knockout mice. RESULTS …