Highlights•MK endomitosis is associated with both a defect in cytokinesis and
karyokinesis.•A myosin II accumulation defect at the furrow induces the cytokinesis
failure.•MK polyploidization and maturation have close transcriptional regulation.•MK
ploidization is functionally important for efficient platelet production.•MK ploidy is altered in
many pathologies but associated with maturation defects.In mammals, platelets are
produced in the blood by cytoplasmic fragmentation of megakaryocytes (MKs). Platelet …